In Ewing sarcoma, an abnormal protein formed by the fusion of two genes can activate repetitive DNA regions that normally ...

Researchers used a vector-free CRISPR activation system to boost dopamine biosynthesis genes in cellular models of ...

A new research paper titled "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes" has been published in Aging. While advanced age is widely ...

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

In Ewing sarcoma, an abnormal protein formed by the fusion of two genes can activate repetitive DNA regions that normally remain silenced and turn ...

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

Two kinases, ATM and DNA-PKcs, control rapid responses to DNA double-strand breaks (DSBs). The paradigm for ATM control is recruitment and activation by the Mre11−Rad50−NBS1 (MRN) sensor complex, ...

Scientists have revealed the DNA sequence code of the “initiator,” a crucial sequence that kick-starts gene activation. A machine learning analysis of a half million experimental data points yielded ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated steatohepatitis, have emerged as the most prevalent liver diseases ...

“[...] the biological mechanisms linking aging and osteoarthritis prevalence remain largely unknown.” “In this study, we use irradiation as an acute model of ...