Aminoglycoside-induced nephrotoxicity and ototoxicity is a major clinical problem. To understand how aminoglycosides, including gentamicin, induce cytotoxicity in the kidney proximal tubule and the ...

Background: The clinical evidence base for ototoxicity and nephrotoxicity outcomes with once-daily dosing (ODD) of gentamicin in children is suboptimal. Therapeutic drug monitoring (TDM) in once-daily ...

Aminoglycosides are potent bactericidal agents that act by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and inhibiting protein synthesis. The therapeutic utility of this ...

Aminoglycosides are antibiotics effective against a wide range of bacteria including Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Until now however, their mode of entry into ...

We received an enquiry from an NHS microbiologist about a lack of recommendations in the NICE guideline about when to start treatment with neonatal gentamicin for suspected sepsis if the neonate has ...

Overview: Gentamicin topical is used to treat skin infections. It works by killing certain types of bacteria. The most common side effects of topical gentamicin are skin irritation and itching. Let ...