Cholesterol is a pivotal lipid in the central nervous system, essential for membrane integrity, synaptic transmission and myelin formation. Unlike peripheral tissues, brain cholesterol is synthesised ...

A new study from Washington University School of Medicine in St. Louis identifies a possible way to slow or block progression of age-related macular degeneration, a leading cause of blindness in ...

Millions of people rely on statins, a medication used to lower cholesterol and reduce the risk of heart attack and stroke.

Cancer cells rewire cholesterol metabolism to support rapid proliferation, survival under stress and dissemination. Endogenous cholesterol synthesis via the mevalonate pathway and exogenous uptake ...

Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson’s disease in mice. Published in the open ...

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce ...

*Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or ...

An experimental gene-editing therapy that aims to lower bad cholesterol for the long-term after a single infusion is off to a positive start in an early clinical trial. Researchers running a Phase I ...

A concise, high-yield guide to cholesterol-lowering therapies—statins, Zetia, PCSK9 inhibitors, bempedoic acid, berberine, ...

This drink can support your heart-health routine without added sugar or alcohol.