Diabetes is a lifelong, chronic health condition caused by abnormalities in the body’s production and use of the hormone insulin. Research has shown that the feel-good hormone, dopamine (DA), plays a ...

Researchers elucidate how BHLHE40, a transcriptional repressor activated in pancreatic β-cells as a response to hypoxia, inhibits the expression of the MAFA protein, thereby leading to impaired ...

Obesity increases the body's need for insulin, forcing cells in the pancreas known as beta cells to ramp up insulin ...

How does the body regulate the activity of insulin-producing cells in order to react quickly to changing conditions? Researchers have investigated this question. The hormone insulin plays a central ...

Tirzepatide, a drug approved for diabetes and on the fast track for approval as a weight loss therapy, works through a unique ability to activate two different mechanisms the body uses to control ...

After an initial chemical screening, researchers at the University of Pennsylvania and Weill Cornell Medicine identified the Chk1/Chk2 dual inhibitor AZD-7762 among the strongest to induce insulin ...

Scientists have thought that this excessive insulin secretion is one of the factors that drives the development of obesity-induced pancreatic cancer. But a new study published in Nature Communications ...

When lipid biologist Usha Acharya at the National Cancer Institute (NCI) tinkered with lipid breakdown pathways in Drosophila melanogaster, she observed something intriguing. Blocking a biochemical ...

Researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little. Just over a century has passed since the ...