How p53 mutations drive immunotherapy resistance—and a path to overcome it

Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from ...
News-Medical.Net

Study reveals how p53 mutations cause tumors to resist cancer immunotherapy

Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from ...
Medical Xpress

Molecular mechanism that initiates colon cancer opens new path for prevention

Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental factors and lifestyle, such as poor diet, sedentarism, obesity, smoking or ...
Medical Xpress

Chromatin organization linked to p53 tumor suppression mechanism

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by ...
ascopubs.org

Developing a deep learning algorithm for automated p53 immunohistochemistry digital image analysis in prostate cancer.

Characterizing the clinical and genomic features of androgen indifferent prostate cancer. Distribution of manual p53 scores (rows) and automated digital image analysis (DIA) p53 scores (columns) by ...