Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three ...
Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with ...
A Molecular Cancer review redefines the MAD gene family as a unified HORMA-domain genome surveillance system linking spindle ...
The error-free distribution of genetic material during cell division is important for preventing the development of tumor cells. Prof. Erich Nigg's research group at the Biozentrum, University of ...
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