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Summary 1)Positive Selection: Determines if DP thymocytes(double positive, CD8 , CD4 ) can recognize MHC molecules. This process is mediated by cTEC in the thymic cortex. Successful binding results in the formation of Single Positive (SP) thymocytes (either CD4⁺ or CD8⁺). 2)Negative Selection: Eliminates SP thymocytes that may recognize self-antigens too strongly. This process occurs in the thymic medulla and involves mTEC, dendritic cells, and macrophages.
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